erk1/erk2 mapk signaling pathway
| PAG Title | erk1/erk2 mapk signaling pathway |
| PAG ID | WAG000645 |
| Type | P |
| Source Link |  BioCarta |
| Publication Reference | NA |
| PAG Description | The p44/42 MAP Kise pathway consists of a protein kise cascade linking growth and differentiation sigls with transcription in the nucleus. Growth factor receptors and tyrosine kises activate Ras which in turn activates c-Raf, MEK, and MAP kise. Activated p44/42 MAP Kise translocates to the nucleus and activates transcription by phosphorylation of kises such as p90 RSK, MSK, and transcription factors such as ELK-1 and Stat3. The importance of this pathway in both growth control and development has been demonstrated via the transforming properties of various mutant forms of Ras, Raf, MEK and by their effects on development. Sigl amplification and the potential for crosstalk appear to be important features of this regulatory network. |
| Species | Homo sapiens |
| nCoCo Score | 2,446 |
| Base PAG ID | WAG000645 |
| Human Phenotyte Annotation | |
| Curator | PAGER curation team |
| Curator Contact | PAGER-contact@googlegroups.com |
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